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KMID : 0371420140860010016
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Annals of Surgical Treatment and Research
2014 Volume.86 No. 1 p.16 ~ p.21
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Leptomeningeal carcinomatosis from gastric cancer: single institute retrospective analysis of 9 cases
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Kim Nam-Hee
Kim Ji-Hyun
Chin Hyung-Min
Jun Kyong-Hwa
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Abstract
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Purpose: The aim of this study is to investigate the clinical features and outcomes of 9 consecutive patients who suffered with leptomeningeal carcinomatosis (LMC) originating from gastric cancer.
Methods: Between January 1995 and December 2010, we retrospectively reviewed the medical records of 9 patients with gastric LMC who had been treated at St. Vincent’s Hospital, The Catholic University of Korea.
Results: With the exception of 1 patient, the primary gastric cancer was Borrmann type III or IV, and 5 cases had poorly differentiated or signet ring cell histology. TNM stage of the primary gastric cancer was III in 6 patients. The median interval from diagnosis of the primary malignancy to the diagnosis of LMC was 9 months. Headache (6 cases), altered mental status (4 cases), and dysarthria (3 cases) were presenting symptoms of LMC. Computed tomography findings were abnormal in 4 of 7 cases, while magnetic resonance imaging revealed abnormality in 4 of 5 cases. Radiation therapy was administered to 5 patients and intrathecal chemotherapy was administered to only 1 patient. Median overall survival duration from the diagnosis of LMC was 3 months.
Conclusion: LMC originating from gastric cancer had a fatal clinical course and treatment strategies remain challenging.
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KEYWORD
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Stomach neoplasms, Neoplasm metastasis, Meningeal carcinomatosis, Prognosis
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